Award Recipients

Elucidating the interplay of Warburg metabolism, membrane potential, and signaling in cancer
Markus Basan, PhD (Harvard Medical School)

Elucidating the role of ciliary transport in polycystic kidney disease pathogenesis
Alan Brown, PhD (Harvard Medical School)

Discovery and manipulation of gut bacterial chemistry for the betterment of human health
Sloan Devlin, PhD (Harvard Medical School)

The rulebook of molecular recognition: Lessons from chemosensory receptors
Josefina del Mármol, PhD (Harvard Medical School)

Mechanisms of transcription, replication, and DNA repair
Lucas Farnung, PhD (Harvard Medical School)

Immunological control of lung homeostasis and repair
Ruth Franklin, PhD (Harvard Medical School)

Messengers of mayhem: Unveiling the impact of chimeric mRNA in inflammatory and neurodegenerative disease
Ruaidhri Jackson, PhD (Harvard Medical School)

Dissecting circuit motifs of innate and adaptive behaviors
Wei-Chung Lee, PhD (Harvard Medical School)

Dissecting specialized secretory biosynthetic mechanisms
Susan Shao, PhD (Harvard Medical School)

Chemical rescue of somatic mutations in cancer
Qinheng Zheng, PhD (Harvard Medical School)

Treating Fragile X syndrome via cytosine-guanine-guanine repeat contraction
Jeannie Lee, MD, PhD (Massachusetts General Hospital)
 
Preparation of intravenous oxygen for a first-in-human clinical trial
John Kheir, MD (Boston Children’s Hospital) and Yifeng Peng, PhD (Boston Children’s Hospital)
 
Brain selective modulation of adrenergic receptors to treat Parkinson’s Disease
Kevin Hodgetts, PhD (Brigham and Women’s Hospital)

Dual-targeted “OR-logic” gated CAR T cell therapy to achieve cure in multiple myeloma
Eric Smith, MD, PhD (Harvard Medical School/Dana-Farber Cancer Institute)
 
Development of allosteric EGFR inhibitor EAI-432 for non-small cell lung cancer
Michael Eck, MD, PhD (Harvard Medical School/Dana-Farber Cancer Institute) and David Scott (Dana-Farber Cancer Institute)
 
Off-the-shelf tissue for cartilage repair
April Craft, PhD (Harvard University/Boston Children’s Hospital)
 
Sidestepping iron restriction to treat anemia
Eric Gale, PhD (Harvard Medical School/Massachusetts General Hospital)
 
Enhancing activity of CAR T cells for the treatment of multiple myeloma
Mohammad Rashidian, PhD (Harvard Medical School/Dana-Farber Cancer Institute)

β-Carboline GABAA partial-PAMs for essential tremor and related disorders
Kevin Hodgetts, PhD (Harvard Medical School/Brigham and Women’s Hospital)

Targeting R-loop and mRNA dependent repair pathway in cancer therapy
Li Lan, PhD (Harvard Medical School/Massachusetts General Hospital) and Lee Zou (Harvard Medical School/Massachusetts General Hospital)

Targeted treatment of pemphigus vulgaris
Mohammad Rashidian, PhD (Harvard Medical School/Dana Farber Cancer Institute), Ramon Almela (Tufts University), and Erin Wei (Nebraska Medical Center)

Identifying small-molecule therapies for telomere diseases

Suneet Agarwal, MD, PhD (HMS Associate Professor of Pediatrics at Boston Children’s Hospital)

Gene therapy for congenital deafness and blindness

David Corey, PhD (Bertarelli Professor of Translational Medical Science, Blavatnik Institute at HMS)

Protein therapy for frozen shoulder

Ara Nazarian, Dr. Sc. (HMS Professor of Orthopedic Surgery at Beth Israel Deaconess Medical Center)

Treating pediatric anemia with gene therapy

Vijay Sankaran, MD, PhD (HMS Associate Professor of Pediatrics at Boston Children’s Hospital)

Therapeutic gene editing of ELANE for severe congenital neutropenia

Daniel Bauer, MD, PhD (Boston Children’s Hospital)

Selectin inhibitors for prevention of cancer-associated venous thromboembolism 

Elliot Chaikof, MD, PhD (Beth Israel Deaconess Medical Center)

A novel therapy to achieve insulin-independent glycemic control in type 1 diabetes

Christiane Ferran, MD, PhD (Beth Israel Deaconess Medical Center)

A first-in-class therapeutic antibody for treatment of asthma 

Steven Greenberg, MD (Brigham and Women’s Hospital)

Antisense oligonucleotide-based progranulin augmentation therapy in neurodegenerative diseases 

Peter Park, PhD (Harvard Medical School)